Location: Home > Professor
Li Cui
Highest Education:
1799 Jimei Road, Xiamen
Zip Code:

Education and Appointments:


2002-2008: PhD, Xiamen University, Xiamen, P. R. China
2007: visiting student, Southampton University, Southampton, UK
1998-2002: BSc, Xiamen University, Xiamen, P. R. China


2019.01-Present: Professor, Institute of Urban Environment, CAS
2010.09-2018.12: Associate Professor, Institute of Urban Environment, CAS
2008.09-2010.09: Assistant Professor, Institute of Urban Environment, CAS
2015.08- 2016.02: Visiting scholar, Oxford University, UK
2015.02- 2015.07: Visiting scholar, Lancaster University, UK
2009.11- 2010.02: Visiting scholar, Bern University, Switzerland

Main academic contributions:
Research Interest:
Development of single-cell spectroscopic (Raman and fluorescence) techniques and molecular tools for investigating environmental microorganisms, including antibiotic resistant bacteria and resistance genes (ARGs), functional bacteria driving N and P biogeochemical cycling, biofilms and microplastics. She served as the editor of mSystems and obtained NSFC for outstanding young scholar.
Selected Publications:

1. Cui, L.*; Li, H.-Z.; Yang, K.; Zhu, L.-J.; Xu, F.; Zhu, Y.-G., Raman biosensor and molecular tools for integrated monitoring of pathogens and antimicrobial resistance in wastewater Trac-Trend Anal Chem 2021, 143, 116415.
2. Chen, Q.-L.; Hu, H.-W.; He, Z.-Y.; Cui, L.; Zhu, Y.-G.; He, J.-Z., Potential of indigenous crop microbiomes for sustainable agriculture Nat Food 2021, 2, 233-240.
3. Morais, C. L. M.; Paraskevaidi, M.; Cui, L.; Fullwood, N. J.; Isabelle, M.; Lima, K. M. G.; Martin-Hirsch, P. L.; Sreedhar, H.; Trevisan, J.; Walsh, M. J.; Zhang, D.; Zhu, Y. G.; Martin, F. L., Standardization of complex biologically derived spectrochemical datasets. Nat Protoc 2019, 14, (5), 1546-1577.
4. Li, R.; Zhu, L.; Yang, K.; Li, H.; Zhu, Y.-G.; Cui, L*., Impact of urbanization on antibiotic resistome in different microplastics: evidence from a large-scale whole river analysis. Environ. Sci. Technol. 2021, 55, (13), 8760-8770.
5. Li, H. Z.; Zhu, D.; Lindhardt, J. H.; Lin, S. M.; Ke, X.; Cui, L., Long-Term Fertilization History Alters Effects of Microplastics on Soil Properties, Microbial Communities, and Functions in Diverse Farmland Ecosystem. Environ. Sci. Technol. 2021, 55, (8), 4658-4668.
6. Yang, K.; Chen, Q. L.; Chen, M. L.; Li, H. Z.; Liao, H.; Pu, Q.; Zhu, Y. G.; Cui, L*., Temporal Dynamics of Antibiotic Resistome in the Plastisphere during Microbial Colonization. Environ. Sci. Technol. 2020, 54, (18), 11322-11332.
7. Li, H.-Z.; Zhang, D.; Yang, K.; An, X.-L.; Pu, Q.; Lin, S.-M.; Su, J.-Q.; Cui, L*., Phenotypic Tracking of Antibiotic Resistance Spread via Transformation from Environment to Clinic by Reverse D2O Single-Cell Raman Probing. Anal. Chem. 2020, 92, (23), 15472-15479.
8. Yang, K.; Li, H. Z.; Zhu, X.; Su, J. Q.; Ren, B.; Zhu, Y. G.; Cui, L*., Rapid Antibiotic Susceptibility Testing of Pathogenic Bacteria Using Heavy-Water-Labeled Single-Cell Raman Spectroscopy in Clinical Samples. Anal. Chem. 2019, 91, 6296-6303.
9. Li, H.-Z.; Bi, Q.-f.; Yang, K.; Zheng, B.-X.; Pu, Q.; Cui, L*., D2O-Isotope-Labeling Approach to Probing Phosphate-Solubilizing Bacteria in Complex Soil Communities by Single-Cell Raman Spectroscopy. Anal. Chem. 2019, 91, (33), 2239-2246.
10. Chen, Q. L.; Zhu, D.; An, X. L.; Ding, J.; Zhu, Y. G.; Cui, L.*, Does nano silver promote the selection of antibiotic resistance genes in soil and plant? Environ Int 2019, 128, 399-406.
11. Cui, L.; Yang, K.; Li, H.-Z.; Zhang, H.; Su, J.-Q.; Paraskevaidi, M.; Martin, F. L.; Ren, B.; Zhu, Y.-G.*, A novel functional single-cell approach to probing nitrogen-fixing bacteria in soil communities by resonance Raman spectroscopy with 15N2 labelling. Anal. Chem. 2018, 90, 5082-5089.
12. Cui, L*.; Yang, K.; Zhou, G.; Huang, W. E*; Zhu, Y. G., Surface-enhanced Raman spectroscopy combined with stable isotope probing to monitor nitrogen assimilation at both bulk and single-cell level. Anal. Chem. 2017, 89, (11), 5793-5800.
13. Chen, Q. L.; An, X. L.; Zhu, Y. G.; Su, J. Q.; Gillings, M. R.; Ye, Z. L.; Cui, L.*, Application of Struvite Alters the Antibiotic Resistome in Soil, Rhizosphere, and Phyllosphere. Environ. Sci. Technol. 2017, 51, (14), 8149-8157.
14. Wang, Y.; Huang, W. E*.; Cui, L.; Wagner, M., Single cell stable isotope probing in microbiology using Raman microspectroscopy. Curr. Opin. Biotechnol. 2016, 41, 34-42.
15. Cui, L.; Zhang, Y.-J.; Huang, W. E.; Zhang, B.-F. M., Francis L; Li, J.-Y.; Zhang, K.-S.; Zhu, Y.-G.*, Surface-Enhanced Raman Spectroscopy for Identification of Heavy Metal Arsenic(V)-Mediated Enhancing Effect on Antibiotic Resistance. Anal. Chem. 2016, 88, (6), 3164–3170.
16. Cui, L.*; Chen, P.; Zhang, B.; Zhang, D.; Li, J.; Martin, F. L.; Zhang, K.*, Interrogating chemical variation via layer-by-layer SERS during biofouling and cleaning of nanofiltration membranes with further investigations into cleaning efficiency. Water Res. 2015, 87, 282-291.
17. Cui, L.*, Chen, P., Chen, S., Yuan, Z., Yu, C., Ren, B. and Zhang, K.*,. In Situ Study of the Antibacterial Activity and Mechanism of Action of Silver Nanoparticles by Surface-Enhanced Raman Spectroscopy. Anal. Chem. 2013, 85(11), 5436-5443.
18. Song, Y.#; Cui, L.#; Lopez, J. A. S.; Xu, J.; Zhu, Y. G.; Thompson, I. P.; Huang, W. E*., Raman-Deuterium Isotope Probing for in-situ identification of antimicrobial resistant bacteria in Thames River. Sci Rep 2017, 7, (1), 16648
19. Chen, Q.-L.; Fan, X.-T.; Zhu, D.; An, X.-L.; Su, J.-Q.; Cui, L*., Effect of biochar amendment on the alleviation of antibiotic resistance in soil and phyllosphere of Brassica chinensis L. Soil Biol. Biochem. 2018, 119, 74-82.
20. Chen, Q. L.; An, X. L.; Li, H.; Zhu, Y. G.; Su, J. Q.; Cui, L.*, Do manure-borne or indigenous soil microorganisms influence the spread of antibiotic resistance genes in manured soil? Soil Biol. Biochem. 2017, 114, 229-237.
21. Chen, P. Y.; Cui, L.*; Zhang, K. S.*, Surface-enhanced Raman spectroscopy monitoring the development of dual-species biofouling on membrane surfaces. J. Membr. Sci. 2015, 473, 36–44.
22. K?gler, M.*; Zhang, B. F.; Cui, L.*; Shi, Y. J.; Yliperttula, M.; Laaksonen, T.; Viitala, T.; Zhang, K., Real-time Raman based approach for identification of biofouling. Sensors and Actuators B: Chemical 2016, 230, 411-421.
23. Zhang, B.; Cui, L.*; Zhang, K.*, Dosage- and time-dependent antibacterial effect of zinc oxide nanoparticles determined by a highly uniform SERS negating undesired spectral variation. Anal Bioanal Chem 2016, 408, (14), 3853-65.
24. Cui, L.*; Butler, H. J.; Martin-Hirsch, P. L.; Martin, F. L.*, Aluminium foil as a potential substrate for ATR-FTIR, transflection FTIR or Raman spectrochemical analysis of biological specimens. Anal Methods-Uk 2016, 8, 481-487.
25. Cui, L., Liu, B., Vonlanthen, D., Mayor, M., Fu, Y.C., Li, J.F. and Wandlowski, T.*, In Situ Gap-Mode Raman Spectroscopy on Single-Crystal Au(100) Electrodes: Tuning the Torsion Angle of 4,4 '-Biphenyldithiols by an Electrochemical Gate Field. J. Am. Chem. Soc. 2011, 133(19), 7332-7335.
26. Cui, L., Yao, M., Ren, B. and Zhang, K.-S.*, Sensitive and Versatile Detection of the Fouling Process and Fouling Propensity of Proteins on Polyvinylidene Fluoride Membranes via Surface-Enhanced Raman Spectroscopy. Anal. Chem.2011, 83(5), 1709-1716.
27. Cui, L.*, Chen, S.D. and Zhang, K.S.*, 2015. Effect of toxicity of Ag nanoparticles on SERS spectral variance of bacteria. Spectroc. Acta Pt. A-Molec. Biomolec. Spectr. 137(0), 1061-1066.
28. Cui, L., Wu, D.Y., Wang, A., Ren, B*. and Tian, Z.Q., 2010. Charge-Transfer Enhancement Involved in the SERS of Adenine on Rh and Pd Demonstrated by Ultraviolet to Visible Laser Excitation. J. Phys. Chem. C 114(39), 16588-16595.
29. Cui, L., Ren, B.* and Tian, Z.Q., 2010. Surface-Enhanced Raman Spectroscopic Study on the Co-adsorption of DNA Bases with Perchlorate. Acta Physico-Chimica Sinica 26(2), 397-402.
30. Cui, L., Mahajan, S., Cole, R.M., Soares, B., Bartlett, P.N., Baumberg, J.J., Hayward, I.P., Ren, B., Russell, A.E*. and Tian, Z.Q., 2009. UV SERS at well ordered Pd sphere segment void (SSV) nanostructures. Phys. Chem. Chem. Phys. 11(7), 1023-1026.
31. Cui, L., Wang, A., Wu, D.Y., Ren, B*. and Tian, Z.Q*., 2008. Shaping and Shelling Pt and Pd Nanoparticles for Ultraviolet Laser Excited Surface-Enhanced Raman Scattering. J. Phys. Chem. C 112(45), 17618-17624.
32. Cui, L., Liu, Z., Duan, S., Wu, D.Y., Ren, B*., Tian, Z.Q. and Zou, S.Z., 2005. Orientation change of adsorbed pyrazine on roughened rhodium electrodes as probed by surface-enhanced Raman spectroscopy. J Phys Chem B 109(37), 17597-17602.

Supported Projects:

1. Single-cell Raman and heavy water labelling identify environmental antibiotic resistant bacteria and reveal evolution of antibiotic resistance. National Science Foundation of China (Grants 21777154) (2018.1-2021.12)
2. In situ surface-enhanced Raman scattering (SERS) study of biofilm on membrane surface: formation process and influencing factors. National Science Foundation of China (Grants 21173208) (2012.1-2015.12)
3. Developing surface-enhanced Raman spectroscopy for in situ study of the membrane fouling mechanism in a membrane bioreactor. National Science Foundation of China (Grants 20903076) (2010.1-2012.12). Finished.
4. SERS study of antibacterial mechanism of graphene and carbon nanotubes. National Science Foundation of Ningbo (Grants 2014A610107)(2014.4.1-2016.3.31)
5. In-situ SERS study of toxic effect of carbon nanomaterials on biofilm. National Science Foundation of Fujian province (Grants 2015J01067) (2015. 4-2018. 4)