In the past decade, great attentions have been focused on the issue of combined pollution of pharmaceuticals and personal care products (PPCPs) and heavy metal ions in surface/groundwater because of its evidence-based risks to aquatic life and human health and the lack of cost-effective and appropriate remediation techniques for removing such combined pollutants. To this end, a worthwhile study aimed at exploring and implementing an integrative technique centered on coremoval and subsequent recycle of PPCPs and heavy metals from waters using carbon supported nano–spinel manganese ferrite (CNSMF) hybrids is featured and conducted in this research program. The primary goal of this research is to develop a simple and straightforward strategy to synthesize less-aggregated and well-dispersed CNSMF while simultaneously improving its coremoval efficacy. Herein, active carbon, graphene, active carbon fibers, and carbon nanotubes are selected as models of carbon supporters to electrostatically, sterically, or electrosterically stabilize and disperse NSMF during the solvo(hydro)thermal or co-precipitation processes. Coremoval practices of PPCPs and heavy metals by CNSMF and NSMF are first presented, along with the influences of varying synthetic conditions on the dispersity and stability of NSMF and the removal of target combined pollutants, which are to be taken into account for optimizing synthesis procedures of CNSMF hybrids. Impacts of single environmental factor and its multiple ones on performance of CNSMF toward PPCPs and heavy metals are also systematically examined. Subsequently, the mechanisms for coremoval of PPCPs and heavy metals by CNSMF under differing conditions and its corresponding kinetic models are probed. Lastly, regenerating practices of used CNSMF hybrids are performed to assess the cost effectivity, manipuility and safety of integrative technique exhibited in this proposal. Research findings from this project are expected to open an avenue to exploring NSMF-related nano-remediation techniques to address the challenges associated with the combined pollution of PPCPs and heavy metals.