Researchers have been working on the development of new low temperature catalysts with high NOx conversion, N₂ selectivity and resistance to SO₂ and H₂O in selective catalytic reduction of NOx with NH3 at 120–300 °C. Here, a series of novel FeO_x–CeO₂–V₂O₅/TiO₂ (FeCeVTi) and MnO_x–CeO₂–V₂O₅ /TiO₂ (MnCeVTi) catalysts were synthesized via a modified solvent-free sol–gel method and their catalytic performances at low temperature were enhanced by doping different contents of Fe or Mn. Among them, the 7%FeCeVTi catalyst (7.0% Ce/Ti and 1.0% V/Ti molar ratio) showed the optimal integrated catalytic performance, whose NOx conversion remained above 92% between 210 and 360 °C and above 86.1% when introducing SO₂ for 24 h at 250 °C with nearly 100% N₂ selectivity. The interaction among Fe, Ce and V species in FeCeVTi catalysts contributed to their higher Ce³⁺/Ce⁴⁺ and surface V⁵⁺ ratio, appropriate redox ability, and more acid sites, which may result in the improvement of their SCR activity and resistance to SO₂. The addition of MnO_x into the CeVTi system increased the catalytic activity below 235 °C, but largely decreased the N₂ selectivity and did not enhance the resistance to SO₂ and H₂O, which may be due to the too high redox ability of the MnCeVTi catalyst. The NH3-SCR reaction on the CeVTi sample followed the E–R mechanism, and the coexistence of E–R and L–H mechanisms was observed on the FeCeVTi catalyst.